6CDO

Structure of vaccine-elicited HIV-1 neutralizing antibody vFP16.02 in complex with HIV-1 fusion peptide residue 512-519

Summary for 6CDO

Related6CDM
DescriptorvFP16.02 Fab heavy chain, vFP16.02 Fab light chain, HIV-1 fusion peptide 512-519, ... (5 entities in total)
Functional Keywordsneutralizing, antibody, fusion peptide, complex, immune system
Biological sourceMus musculus
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Total number of polymer chains3
Total molecular weight50194.81
Authors
Xu, K.,Liu, K.,Kwong, P.D. (deposition date: 2018-02-08, release date: 2018-05-16, Last modification date: 2018-06-20)
Primary citation
Xu, K.,Acharya, P.,Kong, R.,Cheng, C.,Chuang, G.Y.,Liu, K.,Louder, M.K.,O'Dell, S.,Rawi, R.,Sastry, M.,Shen, C.H.,Zhang, B.,Zhou, T.,Asokan, M.,Bailer, R.T.,Chambers, M.,Chen, X.,Choi, C.W.,Dandey, V.P.,Doria-Rose, N.A.,Druz, A.,Eng, E.T.,Farney, S.K.,Foulds, K.E.,Geng, H.,Georgiev, I.S.,Gorman, J.,Hill, K.R.,Jafari, A.J.,Kwon, Y.D.,Lai, Y.T.,Lemmin, T.,McKee, K.,Ohr, T.Y.,Ou, L.,Peng, D.,Rowshan, A.P.,Sheng, Z.,Todd, J.P.,Tsybovsky, Y.,Viox, E.G.,Wang, Y.,Wei, H.,Yang, Y.,Zhou, A.F.,Chen, R.,Yang, L.,Scorpio, D.G.,McDermott, A.B.,Shapiro, L.,Carragher, B.,Potter, C.S.,Mascola, J.R.,Kwong, P.D.
Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24:857-867, 2018
PubMed: 29867235 (PDB entries with the same primary citation)
DOI: 10.1038/s41591-018-0042-6
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.099 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22630.2%2.6%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution