6CB5

Macrophage Migration Inhibitory Factor in complex with a Pyrazole Inhibitor (8g)

6CB5 の概要

• エントリーDOI: 10.2210/pdb6cb5/pdb
• 分子名称: Macrophage migration inhibitory factor, 2-[(naphthalen-2-yl)oxy]-5-(1H-pyrazol-4-yl)benzoic acid, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: cd74 binding, tautomerase, inhibitor, complex, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 38248.31

構造登録者

Krimmer, S.G.,Robertson, M.J.,Jorgensen, W.L. (登録日: 2018-02-02, 公開日: 2018-04-04, 最終更新日: 2023-10-04)

• 主引用文献: Trivedi-Parmar, V.,Robertson, M.J.,Cisneros, J.A.,Krimmer, S.G.,Jorgensen, W.L.; Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor.; ChemMedChem, 13:1092-1097, 2018; PubMed: 29575754; DOI: 10.1002/cmdc.201800158

実験手法

X-RAY DIFFRACTION (1.78 Å)