6CB0

Crystal Structure of the FAK FERM domain

6CB0 の概要

• エントリーDOI: 10.2210/pdb6cb0/pdb
• 分子名称: Focal adhesion kinase 1 (2 entities in total)
• 機能のキーワード: fak ferm domain, src sh3 binding site, transferase
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 86580.29

構造登録者

Dementiev, A.,Marlowe, T. (登録日: 2018-02-01, 公開日: 2019-02-06, 最終更新日: 2023-10-04)

主引用文献

Marlowe, T.,Dementiev, A.,Figel, S.,Rivera, A.,Flavin, M.,Cance, W.
High resolution crystal structure of the FAK FERM domain reveals new insights on the Druggability of tyrosine 397 and the Src SH3 binding site.
BMC Mol Cell Biol, 20:10-10, 2019

PubMed Abstract: Focal Adhesion Kinase (FAK) is a major cancer drug target that is involved in numerous aspects of tumor progression and survival. While multiple research groups have developed ATP-competitive small molecule inhibitors that target the kinase enzyme, recent attention has been focused on the FAK FERM (Band 4.1, Ezrin, Radixin, Moesin) domain that contains key residue Y397 and contributes to many protein-protein interactions. Previous x-ray crystal structures of the FAK FERM domain gave conflicting results on the structure of the Y397 region and therefore the overall druggability.

PubMed: 31109284
DOI: 10.1186/s12860-019-0193-4

実験手法

X-RAY DIFFRACTION (1.97 Å)