6C99

Crystal structure of FcRn bound to UCB-303

Summary for 6C99

• Entry DOI: 10.2210/pdb6c99/pdb
• Descriptor: IgG receptor FcRn large subunit p51, Beta-2-microglobulin, methyl 7-(3,5-difluorophenyl)-5-(pyridin-3-yl)[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylate, ... (7 entities in total)
• Functional Keywords: neonatal fc receptor, fcrn, inhibitor, beta 2 microglobulin, b2m, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 85920.95

Authors

Fox III, D.,Abendroth, J.,Porter, J.,Deboves, H. (deposition date: 2018-01-25, release date: 2018-05-30, Last modification date: 2020-07-29)

• Primary citation: Stoppler, D.,Macpherson, A.,Smith-Penzel, S.,Basse, N.,Lecomte, F.,Deboves, H.,Taylor, R.D.,Norman, T.,Porter, J.,Waters, L.C.,Westwood, M.,Cossins, B.,Cain, K.,White, J.,Griffin, R.,Prosser, C.,Kelm, S.,Sullivan, A.H.,Fox, D.,Carr, M.D.,Henry, A.,Taylor, R.,Meier, B.H.,Oschkinat, H.,Lawson, A.D.; Insight into small molecule binding to the neonatal Fc receptor by X-ray crystallography and 100 kHz magic-angle-spinning NMR.; PLoS Biol., 16:e2006192-e2006192, 2018; PubMed: 29782488; DOI: 10.1371/journal.pbio.2006192

Experimental method

X-RAY DIFFRACTION (2 Å)