6C83
Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP
Summary for 6C83
| Entry DOI | 10.2210/pdb6c83/pdb |
| Descriptor | Aurora kinase A, Mb2 Monobody, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER (3 entities in total) |
| Functional Keywords | transferase, aurora a, monobody, amppcp, kinase, activation, allostery, cell cycle, cancer, transferase-inhibitor complex, transferase/inhibitor |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 86699.90 |
| Authors | Hoemberger, M.,Kutter, S.,Zorba, A.,Nguyen, V.,Shohei, A.,Shohei, K.,Kern, D. (deposition date: 2018-01-24, release date: 2019-02-27, Last modification date: 2023-10-04) |
| Primary citation | Zorba, A.,Nguyen, V.,Koide, A.,Hoemberger, M.,Zheng, Y.,Kutter, S.,Kim, C.,Koide, S.,Kern, D. Allosteric modulation of a human protein kinase with monobodies. Proc.Natl.Acad.Sci.USA, 116:13937-13942, 2019 Cited by PubMed: 31239342DOI: 10.1073/pnas.1906024116 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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