6C83

Structure of Aurora A (122-403) bound to inhibitory Monobody Mb2 and AMPPCP

6C83 の概要

• エントリーDOI: 10.2210/pdb6c83/pdb
• 分子名称: Aurora kinase A, Mb2 Monobody, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER (3 entities in total)
• 機能のキーワード: transferase, aurora a, monobody, amppcp, kinase, activation, allostery, cell cycle, cancer, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 86699.90

構造登録者

Hoemberger, M.,Kutter, S.,Zorba, A.,Nguyen, V.,Shohei, A.,Shohei, K.,Kern, D. (登録日: 2018-01-24, 公開日: 2019-02-27, 最終更新日: 2023-10-04)

• 主引用文献: Zorba, A.,Nguyen, V.,Koide, A.,Hoemberger, M.,Zheng, Y.,Kutter, S.,Kim, C.,Koide, S.,Kern, D.; Allosteric modulation of a human protein kinase with monobodies.; Proc.Natl.Acad.Sci.USA, 116:13937-13942, 2019; PubMed: 31239342; DOI: 10.1073/pnas.1906024116

実験手法

X-RAY DIFFRACTION (2.55 Å)