6C7W

Carbonic anhydrase 2 in complex with [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE inhibitor

6C7W の概要

• エントリーDOI: 10.2210/pdb6c7w/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, ... (5 entities in total)
• 機能のキーワード: human carbonic anhydrase ii; inhibitor; natural product, lyase, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29723.78

構造登録者

Peat, T.S.,Mujumdar, P.,Poulsen, S.A. (登録日: 2018-01-23, 公開日: 2018-05-23, 最終更新日: 2023-10-04)

• 主引用文献: Mujumdar, P.,Bua, S.,Supuran, C.T.,Peat, T.S.,Poulsen, S.A.; Synthesis, structure and bioactivity of primary sulfamate-containing natural products.; Bioorg. Med. Chem. Lett., 28:3009-3013, 2018; PubMed: 29685656; DOI: 10.1016/j.bmcl.2018.04.038

実験手法

X-RAY DIFFRACTION (1.28 Å)