6C6K

Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex

6C6K の概要

• エントリーDOI: 10.2210/pdb6c6k/pdb
• 分子名称: Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced protein with tetratricopeptide repeats 3, RNA (5'-R((M7G)*P*AP*UP*AP*GP*GP*CP*GP*GP*CP*G)-3'), ... (5 entities in total)
• 機能のキーワード: innate immunity, interferon stimulated genes, host defense, antiviral, self/non-self rna recognition, pathogen associated molecular patterns, flavivirus, rna binding protein-rna complex, rna binding protein/rna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 125662.93

構造登録者

Amarasinghe, G.K.,Leung, D.W.,Johnson, B.,Xu, W. (登録日: 2018-01-18, 公開日: 2018-04-04, 最終更新日: 2024-03-06)

• 主引用文献: Johnson, B.,VanBlargan, L.A.,Xu, W.,White, J.P.,Shan, C.,Shi, P.Y.,Zhang, R.,Adhikari, J.,Gross, M.L.,Leung, D.W.,Diamond, M.S.,Amarasinghe, G.K.; Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.; Immunity, 48:487-499.e5, 2018; PubMed: 29525521; DOI: 10.1016/j.immuni.2018.01.014

実験手法

X-RAY DIFFRACTION (2.54 Å)