6C48

Crystal structure of B-Myb-LIN9-LIN52 complex

6C48 の概要

• エントリーDOI: 10.2210/pdb6c48/pdb
• 分子名称: Protein lin-9 homolog, Myb-related protein B, Protein lin-52 homolog, ... (5 entities in total)
• 機能のキーワード: myb, b-myb, lin52, lin9, mmb, muvb, cell cycle, cell cycle-dna binding complex, cell cycle/dna binding
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 51136.46

構造登録者

Guiley, K.Z.,Tripathi, S.M.,Rubin, S.M. (登録日: 2018-01-11, 公開日: 2018-09-19, 最終更新日: 2024-12-25)

主引用文献

Guiley, K.Z.,Iness, A.N.,Saini, S.,Tripathi, S.,Lipsick, J.S.,Litovchick, L.,Rubin, S.M.
Structural mechanism of Myb-MuvB assembly.
Proc. Natl. Acad. Sci. U.S.A., 115:10016-10021, 2018

PubMed Abstract: The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb-MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation.

PubMed: 30224471
DOI: 10.1073/pnas.1808136115

実験手法

X-RAY DIFFRACTION (2.32 Å)