6C2W

Crystal structure of human prothrombin mutant S101C/A470C

6C2W の概要

• エントリーDOI: 10.2210/pdb6c2w/pdb
• 分子名称: Prothrombin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, kringle, enzyme mechanism, coagulation factor, blood clotting
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 134120.52

構造登録者

Chinnaraj, M.,Chen, Z.,Pelc, L.,Grese, Z.,Bystranowska, D.,Di Cera, E.,Pozzi, N. (登録日: 2018-01-09, 公開日: 2018-02-28, 最終更新日: 2023-11-15)

• 主引用文献: Chinnaraj, M.,Chen, Z.,Pelc, L.A.,Grese, Z.,Bystranowska, D.,Di Cera, E.,Pozzi, N.; Structure of prothrombin in the closed form reveals new details on the mechanism of activation.; Sci Rep, 8:2945-2945, 2018; PubMed: 29440720; DOI: 10.1038/s41598-018-21304-1

実験手法

X-RAY DIFFRACTION (4.12 Å)