6C2R

Aurora A ligand complex

Summary for 6C2R

• Entry DOI: 10.2210/pdb6c2r/pdb
• Descriptor: Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: protein kinase, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 32218.28

Authors

Antonysamy, S.,Pustilnik, A.,Manglicmot, D.,Froning, K.,Weichert, K.,Wasserman, S. (deposition date: 2018-01-08, release date: 2019-01-23, Last modification date: 2024-03-13)

• Primary citation: Gong, X.,Du, J.,Parsons, S.H.,Merzoug, F.F.,Webster, Y.,Iversen, P.W.,Chio, L.C.,Van Horn, R.D.,Lin, X.,Blosser, W.,Han, B.,Jin, S.,Yao, S.,Bian, H.,Ficklin, C.,Fan, L.,Kapoor, A.,Antonysamy, S.,Mc Nulty, A.M.,Froning, K.,Manglicmot, D.,Pustilnik, A.,Weichert, K.,Wasserman, S.R.,Dowless, M.,Marugan, C.,Baquero, C.,Lallena, M.J.,Eastman, S.W.,Hui, Y.H.,Dieter, M.Z.,Doman, T.,Chu, S.,Qian, H.R.,Ye, X.S.,Barda, D.A.,Plowman, G.D.,Reinhard, C.,Campbell, R.M.,Henry, J.R.,Buchanan, S.G.; Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.; Cancer Discov, 9:248-263, 2019; PubMed: 30373917; DOI: 10.1158/2159-8290.CD-18-0469

Experimental method

X-RAY DIFFRACTION (1.96 Å)