6C2R

Aurora A ligand complex

6C2R の概要

• エントリーDOI: 10.2210/pdb6c2r/pdb
• 分子名称: Aurora kinase A, SULFATE ION, (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid, ... (4 entities in total)
• 機能のキーワード: protein kinase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32218.28

構造登録者

Antonysamy, S.,Pustilnik, A.,Manglicmot, D.,Froning, K.,Weichert, K.,Wasserman, S. (登録日: 2018-01-08, 公開日: 2019-01-23, 最終更新日: 2024-03-13)

• 主引用文献: Gong, X.,Du, J.,Parsons, S.H.,Merzoug, F.F.,Webster, Y.,Iversen, P.W.,Chio, L.C.,Van Horn, R.D.,Lin, X.,Blosser, W.,Han, B.,Jin, S.,Yao, S.,Bian, H.,Ficklin, C.,Fan, L.,Kapoor, A.,Antonysamy, S.,Mc Nulty, A.M.,Froning, K.,Manglicmot, D.,Pustilnik, A.,Weichert, K.,Wasserman, S.R.,Dowless, M.,Marugan, C.,Baquero, C.,Lallena, M.J.,Eastman, S.W.,Hui, Y.H.,Dieter, M.Z.,Doman, T.,Chu, S.,Qian, H.R.,Ye, X.S.,Barda, D.A.,Plowman, G.D.,Reinhard, C.,Campbell, R.M.,Henry, J.R.,Buchanan, S.G.; Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of theRB1Tumor Suppressor Gene.; Cancer Discov, 9:248-263, 2019; PubMed: 30373917; DOI: 10.1158/2159-8290.CD-18-0469

実験手法

X-RAY DIFFRACTION (1.96 Å)