6C2O

Crystal structure of HCV NS3/4A protease variant Y56H in complex with danoprevir

Summary for 6C2O

• Entry DOI: 10.2210/pdb6c2o/pdb
• Descriptor: NS3 protease, (2R,6S,12Z,13aS,14aR,16aS)-6-[(tert-butoxycarbonyl)amino]-14a-[(cyclopropylsulfonyl)carbamoyl]-5,16-dioxo-1,2,3,5,6,7,8 ,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoro-2H-isoindole-2-carboxylate, ZINC ION, ... (5 entities in total)
• Functional Keywords: ns3/4a protease, hepatitis c virus, drug resistance, protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus
• Total number of polymer chains: 1
• Total formula weight: 21880.10

Authors

Matthew, A.N.,Schiffer, C.A. (deposition date: 2018-01-08, release date: 2019-01-16, Last modification date: 2023-10-04)

• Primary citation: Matthew, A.N.,Schiffer, C.A.; Clinical signature variant of HCV NS3/4A protease uses a novel mechanism to confer resistance; To be Published,

Experimental method

X-RAY DIFFRACTION (1.179 Å)