6C2C

The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme

6C2C の概要

• エントリーDOI: 10.2210/pdb6c2c/pdb
• 分子名称: dihydrocoumarin hydrolase, AncDHCH1, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: phosphatase, directed evolution, methyl-parathion hydrolase (mph), hydrolase, a xenobiotic degrading enzyme
• 由来する生物種: Pseudomonas sp.
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63557.91

構造登録者

Hong, N.-S.,Jackson, C.J.,Carr, P.D.,Tokuriki, N.,Baier, F.,Yang, G. (登録日: 2018-01-08, 公開日: 2019-01-16, 最終更新日: 2024-03-13)

• 主引用文献: Yang, G.,Anderson, D.W.,Baier, F.,Dohmen, E.,Hong, N.,Carr, P.D.,Kamerlin, S.C.L.,Jackson, C.J.,Bornberg-Bauer, E.,Tokuriki, N.; Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme.; Nat.Chem.Biol., 15:1120-1128, 2019; PubMed: 31636435; DOI: 10.1038/s41589-019-0386-3

実験手法

X-RAY DIFFRACTION (1.597 Å)