6C1Q
Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727
Summary for 6C1Q
Entry DOI | 10.2210/pdb6c1q/pdb |
Related PRD ID | PRD_002303 |
Descriptor | Soluble cytochrome b562, C5a anaphylatoxin chemotactic receptor 1 chimera, PMX53, 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine (3 entities in total) |
Functional Keywords | gpcr, membrane protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 2 |
Total formula weight | 48978.27 |
Authors | |
Primary citation | Liu, H.,Kim, H.R.,Deepak, R.N.V.K.,Wang, L.,Chung, K.Y.,Fan, H.,Wei, Z.,Zhang, C. Orthosteric and allosteric action of the C5a receptor antagonists. Nat. Struct. Mol. Biol., 25:472-481, 2018 Cited by PubMed: 29867214DOI: 10.1038/s41594-018-0067-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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