6C1I

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907

6C1I の概要

• エントリーDOI: 10.2210/pdb6c1i/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, nonanoic acid, ... (4 entities in total)
• 機能のキーワード: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63558.61

構造登録者

Shang, J.,Fuhrmann, J.,Brust, R.,Kojetin, D.J. (登録日: 2018-01-04, 公開日: 2018-12-12, 最終更新日: 2023-10-04)

• 主引用文献: Brust, R.,Shang, J.,Fuhrmann, J.,Mosure, S.A.,Bass, J.,Cano, A.,Heidari, Z.,Chrisman, I.M.,Nemetchek, M.D.,Blayo, A.L.,Griffin, P.R.,Kamenecka, T.M.,Hughes, T.S.,Kojetin, D.J.; A structural mechanism for directing corepressor-selective inverse agonism of PPAR gamma.; Nat Commun, 9:4687-4687, 2018; PubMed: 30409975; DOI: 10.1038/s41467-018-07133-w

実験手法

X-RAY DIFFRACTION (2.26 Å)