6C1A

MBD2 in complex with methylated DNA

Summary for 6C1A

• Entry DOI: 10.2210/pdb6c1a/pdb
• Descriptor: Methyl-CpG-binding domain protein 2, dna strand 1, complement to dna strand 1, ... (5 entities in total)
• Functional Keywords: dna methylation, dna binding, structural genomics, structural genomics consortium, sgc, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : Q9UBB5
• Total number of polymer chains: 8
• Total formula weight: 49844.33

Authors

Liu, K.,Xu, C.,Tempel, W.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2018-01-04, release date: 2018-02-14, Last modification date: 2024-04-03)

• Primary citation: Liu, K.,Xu, C.,Lei, M.,Yang, A.,Loppnau, P.,Hughes, T.R.,Min, J.; Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.; J. Biol. Chem., 293:7344-7354, 2018; PubMed: 29567833; DOI: 10.1074/jbc.RA118.001785

Experimental method

X-RAY DIFFRACTION (2.05 Å)