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6C0S

Factor XIA in complex with the inhibitor methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2- (1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl) carbamate

Summary for 6C0S
Entry DOI10.2210/pdb6c0s/pdb
DescriptorCoagulation factor XI, methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl)carbamate, SULFATE ION, ... (5 entities in total)
Functional Keywordshydrolase-hydrolase inhibitor complex, serine protease, blood coagulation factor, protein inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationSecreted: P03951
Total number of polymer chains1
Total formula weight29105.76
Authors
Sheriff, S. (deposition date: 2018-01-02, release date: 2018-03-07, Last modification date: 2023-10-04)
Primary citationHu, Z.,Wang, C.,Han, W.,Rossi, K.A.,Bozarth, J.M.,Wu, Y.,Sheriff, S.,Myers, J.E.,Luettgen, J.M.,Seiffert, D.A.,Wexler, R.R.,Quan, M.L.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg. Med. Chem. Lett., 28:987-992, 2018
Cited by
PubMed: 29501396
DOI: 10.1016/j.bmcl.2018.02.049
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.35 Å)
Structure validation

217705

건을2024-03-27부터공개중

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