6BZW

Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the GL precursor of the broadly neutralizing antibody AP33

Summary for 6BZW

Entry DOI	10.2210/pdb6bzw/pdb
Descriptor	AP33 GL Heavy Chain, AP33 GL Light Chain, E2 AS412 peptide, ... (4 entities in total)
Functional Keywords	hepatitis c virus, immune system, antibodies, broadly neutralizing antibodies, rational vaccine design, as412, e2, viral protein
Biological source	Mus musculus More
Total number of polymer chains	12
Total formula weight	197574.96
Authors	Tzarum, N.,Aleman, F.,Wilson, I.A.,Law, M. (deposition date: 2017-12-26, release date: 2018-06-20, Last modification date: 2023-10-04)
Primary citation	Aleman, F.,Tzarum, N.,Kong, L.,Nagy, K.,Zhu, J.,Wilson, I.A.,Law, M. Immunogenetic and structural analysis of a class of HCV broadly neutralizing antibodies and their precursors. Proc. Natl. Acad. Sci. U.S.A., 115:7569-7574, 2018 Cited by PubMed: 29954862 DOI: 10.1073/pnas.1802378115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation