6BZI

Crystal structure of halogenase PltM in complex with ethyl mercury and mercury

Summary for 6BZI

Entry DOI	10.2210/pdb6bzi/pdb
Descriptor	Halogenase PltM, CALCIUM ION, MERCURY (II) ION, ... (6 entities in total)
Functional Keywords	halogenase, chlorinase, brominase, iodinase, flavoprotein
Biological source	Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
Total number of polymer chains	4
Total formula weight	240685.00
Authors	Pang, A.H.,Garneau-Tsodikova, S.,Tsodikov, O.V. (deposition date: 2017-12-24, release date: 2019-03-20, Last modification date: 2024-03-13)
Primary citation	Mori, S.,Pang, A.H.,Thamban Chandrika, N.,Garneau-Tsodikova, S.,Tsodikov, O.V. Unusual substrate and halide versatility of phenolic halogenase PltM. Nat Commun, 10:1255-1255, 2019 Cited by PubMed Abstract: Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase. PubMed: 30890712 DOI: 10.1038/s41467-019-09215-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation