6BZA

Crystal structure of halogenase PltM in complex with phloroglucinol and FAD

6BZA の概要

• エントリーDOI: 10.2210/pdb6bza/pdb
• 分子名称: Halogenase PltM, benzene-1,3,5-triol, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• 機能のキーワード: halogenase, chlorinase, brominase, iodinase, flavoprotein
• 由来する生物種: Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 235416.79

構造登録者

Pang, A.H.,Garneau-Tsodikova, S.,Tsodikov, O.V. (登録日: 2017-12-22, 公開日: 2019-03-20, 最終更新日: 2024-03-13)

主引用文献

Mori, S.,Pang, A.H.,Thamban Chandrika, N.,Garneau-Tsodikova, S.,Tsodikov, O.V.
Unusual substrate and halide versatility of phenolic halogenase PltM.
Nat Commun, 10:1255-1255, 2019

PubMed Abstract: Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.

PubMed: 30890712
DOI: 10.1038/s41467-019-09215-9

実験手法

X-RAY DIFFRACTION (2.6 Å)