6BVK
Ras:SOS:Ras in complex with a small molecule activator
Summary for 6BVK
Entry DOI | 10.2210/pdb6bvk/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total) |
Functional Keywords | ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 95872.00 |
Authors | Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2017-12-13, release date: 2018-10-24, Last modification date: 2019-05-01) |
Primary citation | Abbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W. Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling. J. Med. Chem., 61:6002-6017, 2018 Cited by PubMed: 29856609DOI: 10.1021/acs.jmedchem.8b00360 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.799 Å) |
Structure validation
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