6BVJ

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6BVJ

• Entry DOI: 10.2210/pdb6bvj/pdb
• Descriptor: GTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
• Functional Keywords: ras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 95984.51

Authors

Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2017-12-13, release date: 2018-10-24, Last modification date: 2023-11-15)

• Primary citation: Abbott, J.R.,Hodges, T.R.,Daniels, R.N.,Patel, P.A.,Kennedy, J.P.,Howes, J.E.,Akan, D.T.,Burns, M.C.,Sai, J.,Sobolik, T.,Beesetty, Y.,Lee, T.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.; Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.; J. Med. Chem., 61:6002-6017, 2018; PubMed: 29856609; DOI: 10.1021/acs.jmedchem.8b00360

Experimental method

X-RAY DIFFRACTION (1.747 Å)