6BUT
Solution structure of full-length apo mammalian calmodulin bound to the IQ motif of the human voltage-gated sodium channel NaV1.2
Summary for 6BUT
Entry DOI | 10.2210/pdb6but/pdb |
NMR Information | BMRB: 27095 |
Descriptor | Calmodulin-1, Sodium channel protein type 2 subunit alpha (2 entities in total) |
Functional Keywords | calcium-binding protein, metal transport ion channel neuronal molecular recognition, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 20403.76 |
Authors | Mahling, R.,Kilpatrick, A.M.,Shea, M.A. (deposition date: 2017-12-11, release date: 2019-06-19, Last modification date: 2024-05-01) |
Primary citation | Mahling, R.,Hovey, L.,Isbell, H.M.,Marx, D.C.,Miller, M.S.,Kilpatrick, A.M.,Weaver, L.D.,Yoder, J.B.,Kim, E.H.,Andresen, C.N.J.,Li, S.,Shea, M.A. Na V 1.2 EFL domain allosterically enhances Ca 2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD. Structure, 2021 Cited by PubMed: 33770503DOI: 10.1016/j.str.2021.03.002 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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