6BUS

Extended E2 DNA-binding domain of the Bovine Papillomavirus-1

6BUS の概要

• エントリーDOI: 10.2210/pdb6bus/pdb
• 分子名称: Regulatory protein E2 (2 entities in total)
• 機能のキーワード: open reading frame, e2, bpv-1, dna binding protein
• 由来する生物種: Bovine papillomavirus type 1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 46308.65

構造登録者

Leroy, L.M.D.,Barbosa, J.A.R.G.,Polikarpov, I.,Pinheiro, C.B. (登録日: 2017-12-11, 公開日: 2018-01-10, 最終更新日: 2023-10-04)

主引用文献

Leroy, L.,Barbosa, J.A.R.G.,de Prat-Gay, G.,Polikarpov, I.,Pinheiro, C.B.
The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1.
Proteins, 88:106-112, 2020

PubMed Abstract: Bovine papillomavirus proteins were extensively studied as a prototype for the human papillomavirus. Here, the crystal structure of the extended E2 DNA-binding domain of the dominant transcription regulator from the bovine papillomavirus strain 1 is described in the space group P3 21. We found two protein functional dimers packed in the asymmetric unit. This new protein arrangement inside the crystal led to the reduction of the mobility of a previously unobserved loop directly involved in the protein-DNA interaction, which was then modeled for the first time.

PubMed: 31299114
DOI: 10.1002/prot.25773

実験手法

X-RAY DIFFRACTION (1.9 Å)