6BSK

Human PIM1 kinase in complex with compound 12b

6BSK の概要

• エントリーDOI: 10.2210/pdb6bsk/pdb
• 分子名称: Serine/threonine-protein kinase pim-1, 1,2-ETHANEDIOL, 4-{6-[6-(propan-2-ylamino)-1H-indazol-1-yl]pyrazin-2-yl}benzoic acid, ... (5 entities in total)
• 機能のキーワード: kinase, pim1, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32719.01

構造登録者

Ferguson, A.D. (登録日: 2017-12-03, 公開日: 2018-03-21, 最終更新日: 2023-10-04)

• 主引用文献: Gingipalli, L.,Block, M.H.,Bao, L.,Cooke, E.,Dakin, L.A.,Denz, C.R.,Ferguson, A.D.,Johannes, J.W.,Larsen, N.A.,Lyne, P.D.,Pontz, T.W.,Wang, T.,Wu, X.,Wu, A.,Zhang, H.J.,Zheng, X.,Dowling, J.E.,Lamb, M.L.; Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases.; Bioorg. Med. Chem. Lett., 28:1336-1341, 2018; PubMed: 29559278; DOI: 10.1016/j.bmcl.2018.03.018

実験手法

X-RAY DIFFRACTION (2.573 Å)