6BSH

Structure of HIV-1 RT complexed with RNA/DNA hybrid in the RNA hydrolysis mode

Summary for 6BSH

• Entry DOI: 10.2210/pdb6bsh/pdb
• Descriptor: REVERSE TRANSCRIPTASE P66 SUBUNIT, REVERSE TRANSCRIPTASE P51 SUBUNIT, DNA (5'-D(*GP*TP*AP*TP*GP*CP*CP*AP*CP*TP*AP*GP*TP*TP*AP*TP*TP*GP*TP*GP*GP*CP*C)-3'), ... (9 entities in total)
• Functional Keywords: hiv-rt, dna-rna complex, rnase h, viral protein, viral protein-dna-rna complex, viral protein-dna-rna-inhibitor complex, viral protein/dna/rna/inhibitor
• Biological source: Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI); More
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 4
• Total formula weight: 131604.39

Authors

Tian, L.,Kim, M.,Yang, W. (deposition date: 2017-12-03, release date: 2018-01-03, Last modification date: 2022-03-23)

• Primary citation: Tian, L.,Kim, M.S.,Li, H.,Wang, J.,Yang, W.; Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid.; Proc. Natl. Acad. Sci. U.S.A., 115:507-512, 2018; PubMed: 29295939; DOI: 10.1073/pnas.1719746115

Experimental method

X-RAY DIFFRACTION (2.649 Å)