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6BS2

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 8b

Summary for 6BS2
Entry DOI10.2210/pdb6bs2/pdb
Related6BR1 6BRF 6BRY
DescriptorTubulin alpha-1B chain, 1-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywordsmicrotubule inhibitor, colchicine cancer, cell cycle
Biological sourceRattus norvegicus (Rat)
More
Total number of polymer chains6
Total formula weight265126.73
Authors
Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-12-01, release date: 2018-06-27, Last modification date: 2024-03-13)
Primary citationBanerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61:1704-1718, 2018
Cited by
PubMed: 29406710
DOI: 10.1021/acs.jmedchem.7b01858
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

數據於2024-03-27公開中

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