6BS2
Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 8b
Summary for 6BS2
Entry DOI | 10.2210/pdb6bs2/pdb |
Related | 6BR1 6BRF 6BRY |
Descriptor | Tubulin alpha-1B chain, 1-(3,6-dimethyl[1,2]oxazolo[5,4-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine cancer, cell cycle |
Biological source | Rattus norvegicus (Rat) More |
Total number of polymer chains | 6 |
Total formula weight | 265126.73 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-12-01, release date: 2018-06-27, Last modification date: 2024-03-13) |
Primary citation | Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710DOI: 10.1021/acs.jmedchem.7b01858 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report