6BRY
Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a
Summary for 6BRY
Entry DOI | 10.2210/pdb6bry/pdb |
Related | 6BR1 6BRF |
Descriptor | Tubulin alpha-1B chain, 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine cancer, cell cycle |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 265137.54 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-12-01, release date: 2018-06-27, Last modification date: 2024-03-13) |
Primary citation | Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710DOI: 10.1021/acs.jmedchem.7b01858 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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