6BRY

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 6a

Summary for 6BRY

Entry DOI	10.2210/pdb6bry/pdb
Related	6BR1 6BRF
Descriptor	Tubulin alpha-1B chain, 1-(2-chlorofuro[3,2-d]pyrimidin-4-yl)-6-methoxy-1,2,3,4-tetrahydroquinoline, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
Functional Keywords	microtubule inhibitor, colchicine cancer, cell cycle
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	265137.54
Authors	Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-12-01, release date: 2018-06-27, Last modification date: 2024-03-13)
Primary citation	Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710 DOI: 10.1021/acs.jmedchem.7b01858 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation