6BRB

Novel non-antibody protein scaffold targeting CD40L

Summary for 6BRB

Entry DOI	10.2210/pdb6brb/pdb
Descriptor	CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	tn3 related, tnf ligand related, structural protein-immune system complex, structural protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	25868.92
Authors	Oganesyan, V.,Baca, M.,Thisted, T.,Grinberg, L.,Wu, H.,Dall'Acqua, W.F. (deposition date: 2017-11-30, release date: 2018-12-05, Last modification date: 2023-10-04)
Primary citation	Karnell, J.L.,Albulescu, M.,Drabic, S.,Wang, L.,Moate, R.,Baca, M.,Oganesyan, V.,Gunsior, M.,Thisted, T.,Yan, L.,Li, J.,Xiong, X.,Eck, S.C.,de Los Reyes, M.,Yusuf, I.,Streicher, K.,Muller-Ladner, U.,Howe, D.,Ettinger, R.,Herbst, R.,Drappa, J. A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11:-, 2019 Cited by PubMed: 31019027 DOI: 10.1126/scitranslmed.aar6584 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.82 Å)

Structure validation