6BR1

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a

Summary for 6BR1

DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (12 entities in total)
Functional Keywordsmicrotubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological sourceHomo sapiens (Human)
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Total number of polymer chains6
Total molecular weight264964.36
Authors
Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-11-29, release date: 2018-06-27, Last modification date: 2019-02-20)
Primary citation
Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
J. Med. Chem., 61:1704-1718, 2018
PubMed: 29406710 (PDB entries with the same primary citation)
DOI: 10.1021/acs.jmedchem.7b01858
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.304 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2349 0.0% 1.9% 8.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution