6BR1
Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a
Summary for 6BR1
Entry DOI | 10.2210/pdb6br1/pdb |
Descriptor | Tubulin alpha-1B chain, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | microtubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 264964.36 |
Authors | Kumar, G.,Wang, Y.,Li, W.,White, S.W. (deposition date: 2017-11-29, release date: 2018-06-27, Last modification date: 2024-03-13) |
Primary citation | Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710DOI: 10.1021/acs.jmedchem.7b01858 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.304 Å) |
Structure validation
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