6BR1
Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a
6BR1 の概要
エントリーDOI | 10.2210/pdb6br1/pdb |
分子名称 | Tubulin alpha-1B chain, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
機能のキーワード | microtubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 264964.36 |
構造登録者 | |
主引用文献 | Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D. Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy. J. Med. Chem., 61:1704-1718, 2018 Cited by PubMed: 29406710DOI: 10.1021/acs.jmedchem.7b01858 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.304 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード