6BR1

Tubulin-RB3_SLD-TTL in complex with heterocyclic pyrimidine compound 4a

6BR1 の概要

• エントリーDOI: 10.2210/pdb6br1/pdb
• 分子名称: Tubulin alpha-1B chain, 2-chloro-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)pyrido[2,3-d]pyrimidine, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: microtubule inhibitor, colchicine cancer, cell cycle, cell cycle-inhibitor complex, cell cycle/inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 264964.36

構造登録者

Kumar, G.,Wang, Y.,Li, W.,White, S.W. (登録日: 2017-11-29, 公開日: 2018-06-27, 最終更新日: 2024-03-13)

• 主引用文献: Banerjee, S.,Arnst, K.E.,Wang, Y.,Kumar, G.,Deng, S.,Yang, L.,Li, G.B.,Yang, J.,White, S.W.,Li, W.,Miller, D.D.; Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.; J. Med. Chem., 61:1704-1718, 2018; PubMed: 29406710; DOI: 10.1021/acs.jmedchem.7b01858

実験手法

X-RAY DIFFRACTION (2.304 Å)