6BPL

E. coli MsbA in complex with LPS and inhibitor G907

Summary for 6BPL

• Entry DOI: 10.2210/pdb6bpl/pdb
• Descriptor: Lipid A export ATP-binding/permease protein MsbA, MYRISTIC ACID, DIPHOSPHATE, ... (11 entities in total)
• Functional Keywords: abc transporter, inhibitor, lps, msba, lipid transport
• Biological source: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
• Total number of polymer chains: 2
• Total formula weight: 136482.65

Authors

Ho, H.,Koth, C.M.,Payandeh, J. (deposition date: 2017-11-23, release date: 2018-05-02, Last modification date: 2020-07-29)

• Primary citation: Ho, H.,Miu, A.,Alexander, M.K.,Garcia, N.K.,Oh, A.,Zilberleyb, I.,Reichelt, M.,Austin, C.D.,Tam, C.,Shriver, S.,Hu, H.,Labadie, S.S.,Liang, J.,Wang, L.,Wang, J.,Lu, Y.,Purkey, H.E.,Quinn, J.,Franke, Y.,Clark, K.,Beresini, M.H.,Tan, M.W.,Sellers, B.D.,Maurer, T.,Koehler, M.F.T.,Wecksler, A.T.,Kiefer, J.R.,Verma, V.,Xu, Y.,Nishiyama, M.,Payandeh, J.,Koth, C.M.; Structural basis for dual-mode inhibition of the ABC transporter MsbA.; Nature, 557:196-201, 2018; PubMed: 29720648; DOI: 10.1038/s41586-018-0083-5

Experimental method

X-RAY DIFFRACTION (2.908 Å)