6BNR
Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310)
Summary for 6BNR
Entry DOI | 10.2210/pdb6bnr/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total) |
Functional Keywords | hemoglobin, aromatic aldehyde, antisickling, allosteric effector, alpha-cleft, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 65117.64 |
Authors | Pagare, P.P.,Musayev, F.N.,Safo, M.K. (deposition date: 2017-11-17, release date: 2018-09-05, Last modification date: 2023-10-04) |
Primary citation | Pagare, P.P.,Ghatge, M.S.,Musayev, F.N.,Deshpande, T.M.,Chen, Q.,Braxton, C.,Kim, S.,Venitz, J.,Zhang, Y.,Abdulmalik, O.,Safo, M.K. Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease. Bioorg. Med. Chem., 26:2530-2538, 2018 Cited by PubMed: 29655608DOI: 10.1016/j.bmc.2018.04.015 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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