6BNR

Carbonmonoxy hemoglobin in complex with the antisickling agent 5-methoxy-2-(pyridin-2-ylmethoxy)benzaldehyde (INN310)

6BNR の概要

• エントリーDOI: 10.2210/pdb6bnr/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
• 機能のキーワード: hemoglobin, aromatic aldehyde, antisickling, allosteric effector, alpha-cleft, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65117.64

構造登録者

Pagare, P.P.,Musayev, F.N.,Safo, M.K. (登録日: 2017-11-17, 公開日: 2018-09-05, 最終更新日: 2023-10-04)

• 主引用文献: Pagare, P.P.,Ghatge, M.S.,Musayev, F.N.,Deshpande, T.M.,Chen, Q.,Braxton, C.,Kim, S.,Venitz, J.,Zhang, Y.,Abdulmalik, O.,Safo, M.K.; Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.; Bioorg. Med. Chem., 26:2530-2538, 2018; PubMed: 29655608; DOI: 10.1016/j.bmc.2018.04.015

実験手法

X-RAY DIFFRACTION (1.95 Å)