6BN5
Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2
Summary for 6BN5
Entry DOI | 10.2210/pdb6bn5/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one (3 entities in total) |
Functional Keywords | shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q06124 |
Total number of polymer chains | 2 |
Total formula weight | 121235.48 |
Authors | Blacklow, S.C.,Stams, T.,Fodor, M.,LaRochelle, J.R. (deposition date: 2017-11-16, release date: 2017-12-13, Last modification date: 2023-10-04) |
Primary citation | LaRochelle, J.R.,Fodor, M.,Ellegast, J.M.,Liu, X.,Vemulapalli, V.,Mohseni, M.,Stams, T.,Buhrlage, S.J.,Stegmaier, K.,LaMarche, M.J.,Acker, M.G.,Blacklow, S.C. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg. Med. Chem., 25:6479-6485, 2017 Cited by PubMed: 29089257DOI: 10.1016/j.bmc.2017.10.025 PDB entries with the same primary citation |
Experimental method |
Structure validation
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