6BMU

Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitors SHP099 and SHP244

6BMU の概要

• エントリーDOI: 10.2210/pdb6bmu/pdb
• 関連するPDBエントリー: 6BMR
• 分子名称: Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, 4-[(2-chlorophenyl)methyl]-1-(2-hydroxy-3-methoxyphenyl)[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one, ... (6 entities in total)
• 機能のキーワード: shp2, ptpn11, protein tyrosine phosphatase, phosphatase, allosteric inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q06124
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122706.54

構造登録者

Stams, T.,Fodor, M. (登録日: 2017-11-15, 公開日: 2018-01-17, 最終更新日: 2023-10-04)

• 主引用文献: Fodor, M.,Price, E.,Wang, P.,Lu, H.,Argintaru, A.,Chen, Z.,Glick, M.,Hao, H.X.,Kato, M.,Koenig, R.,LaRochelle, J.R.,Liu, G.,McNeill, E.,Majumdar, D.,Nishiguchi, G.A.,Perez, L.B.,Paris, G.,Quinn, C.M.,Ramsey, T.,Sendzik, M.,Shultz, M.D.,Williams, S.L.,Stams, T.,Blacklow, S.C.,Acker, M.G.,LaMarche, M.J.; Dual Allosteric Inhibition of SHP2 Phosphatase.; ACS Chem. Biol., 13:647-656, 2018; PubMed: 29304282; DOI: 10.1021/acschembio.7b00980

実験手法

X-RAY DIFFRACTION (2.12 Å)