6BL4

Crystal Complex of Cyclooxygenase-2 with indomethacin-ethylenediamine-dansyl conjugate

Summary for 6BL4

Entry DOI	10.2210/pdb6bl4/pdb
Descriptor	Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTOPORPHYRIN IX CONTAINING FE, ... (7 entities in total)
Functional Keywords	protein-inhibitor complex, fluorescent inhibitor, membrane protein, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
Biological source	Mus musculus (Mouse)
Total number of polymer chains	4
Total formula weight	279258.53
Authors	Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (deposition date: 2017-11-09, release date: 2018-11-14, Last modification date: 2023-10-04)
Primary citation	Xu, S.,Uddin, M.J.,Banerjee, S.,Duggan, K.,Musee, J.,Kiefer, J.R.,Ghebreselasie, K.,Rouzer, C.A.,Marnett, L.J. Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site. J.Biol.Chem., 294:8690-8698, 2019 Cited by PubMed: 31000626 DOI: 10.1074/jbc.RA119.007405 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation