6BL3
Crystal Complex of Cyclooxygenase-2 with indomethacin-butyldiamine-dansyl conjugate
Summary for 6BL3
| Entry DOI | 10.2210/pdb6bl3/pdb |
| Descriptor | Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
| Functional Keywords | cyclooxygenase-2, fluorescent inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
| Biological source | Mus musculus (Mouse) |
| Total number of polymer chains | 4 |
| Total formula weight | 279663.11 |
| Authors | Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (deposition date: 2017-11-09, release date: 2018-11-14, Last modification date: 2023-10-04) |
| Primary citation | Xu, S.,Uddin, M.J.,Banerjee, S.,Duggan, K.,Musee, J.,Kiefer, J.R.,Ghebreselasie, K.,Rouzer, C.A.,Marnett, L.J. Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site. J.Biol.Chem., 294:8690-8698, 2019 Cited by PubMed: 31000626DOI: 10.1074/jbc.RA119.007405 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.217 Å) |
Structure validation
Download full validation report
