6BL3

Crystal Complex of Cyclooxygenase-2 with indomethacin-butyldiamine-dansyl conjugate

6BL3 の概要

• エントリーDOI: 10.2210/pdb6bl3/pdb
• 分子名称: Prostaglandin G/H synthase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: cyclooxygenase-2, fluorescent inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 279663.11

構造登録者

Xu, S.,Uddin, M.J.,Banerjee, S.,Marnett, L.J. (登録日: 2017-11-09, 公開日: 2018-11-14, 最終更新日: 2023-10-04)

• 主引用文献: Xu, S.,Uddin, M.J.,Banerjee, S.,Duggan, K.,Musee, J.,Kiefer, J.R.,Ghebreselasie, K.,Rouzer, C.A.,Marnett, L.J.; Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site.; J.Biol.Chem., 294:8690-8698, 2019; PubMed: 31000626; DOI: 10.1074/jbc.RA119.007405

実験手法

X-RAY DIFFRACTION (2.217 Å)