6BKK
Influenza A M2 transmembrane domain bound to amantadine
Summary for 6BKK
Entry DOI | 10.2210/pdb6bkk/pdb |
Descriptor | Matrix protein 2, (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | influenza m2, proton channel, membrane protein, amantadine |
Biological source | Influenza A virus |
Total number of polymer chains | 8 |
Total formula weight | 22408.12 |
Authors | Thomaston, J.L.,DeGrado, W.F. (deposition date: 2017-11-08, release date: 2018-09-19, Last modification date: 2023-10-04) |
Primary citation | Thomaston, J.L.,Polizzi, N.F.,Konstantinidi, A.,Wang, J.,Kolocouris, A.,DeGrado, W.F. Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc., 140:15219-15226, 2018 Cited by PubMed: 30165017DOI: 10.1021/jacs.8b06741 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.995 Å) |
Structure validation
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