6BKF

Lysyl-adenylate form of human LigIV catalytic domain with bound DNA substrate in open conformation

6BKF の概要

• エントリーDOI: 10.2210/pdb6bkf/pdb
• 分子名称: DNA ligase 4, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... (6 entities in total)
• 機能のキーワード: dna double-strand break repair, ligase, nonhomologous end-joining, ligase-dna complex, ligase/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 82033.04

構造登録者

Moon, A.F.,Tumbale, P.P.,Schellenberg, M.J.,Williams, R.S.,Williams, J.G.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, B. (登録日: 2017-11-08, 公開日: 2018-07-18, 最終更新日: 2023-10-04)

• 主引用文献: Kaminski, A.M.,Tumbale, P.P.,Schellenberg, M.J.,Williams, R.S.,Williams, J.G.,Kunkel, T.A.,Pedersen, L.C.,Bebenek, K.; Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis.; Nat Commun, 9:2642-2642, 2018; PubMed: 29980672; DOI: 10.1038/s41467-018-05024-8

実験手法

X-RAY DIFFRACTION (3.25 Å)