6BJO
PICK1 PDZ domain in complex with the small molecule inhibitor BIO124.
Summary for 6BJO
Entry DOI | 10.2210/pdb6bjo/pdb |
Descriptor | PRKCA-binding protein, (2S)-({4-(4-bromophenyl)-1-[1-(tert-butoxycarbonyl)-L-prolyl]piperidine-4-carbonyl}amino)(cyclopentyl)acetic acid (3 entities in total) |
Functional Keywords | pick1 pdz domain inhibitor complex lock and chop, peptide binding protein |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, perinuclear region: Q9NRD5 |
Total number of polymer chains | 2 |
Total formula weight | 28293.91 |
Authors | Marcotte, D.J. (deposition date: 2017-11-06, release date: 2018-01-10, Last modification date: 2018-02-28) |
Primary citation | Marcotte, D.J.,Hus, J.C.,Banos, C.C.,Wildes, C.,Arduini, R.,Bergeron, C.,Hession, C.A.,Baker, D.P.,Lin, E.,Guckian, K.M.,Dunah, A.W.,Silvian, L.F. Lock and chop: A novel method for the generation of a PICK1 PDZ domain and piperidine-based inhibitor co-crystal structure. Protein Sci., 27:672-680, 2018 Cited by PubMed: 29280296DOI: 10.1002/pro.3361 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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