6BG3

Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1

Summary for 6BG3

Entry DOI	10.2210/pdb6bg3/pdb
Descriptor	Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	e3 ligase, hydrolase, ligase-inhibitor complex, ligase/inhibitor
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	1
Total formula weight	44744.81
Authors	Guy, R.K.,Schulman, B.A.,Scott, D.C.,Hammill, J.T. (deposition date: 2017-10-27, release date: 2018-09-26, Last modification date: 2023-10-04)
Primary citation	Hammill, J.T.,Scott, D.C.,Min, J.,Connelly, M.C.,Holbrook, G.,Zhu, F.,Matheny, A.,Yang, L.,Singh, B.,Schulman, B.A.,Guy, R.K. Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61:2680-2693, 2018 Cited by PubMed: 29547696 DOI: 10.1021/acs.jmedchem.7b01277 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation