6BE4

Crystal structure of a polysaccharide-binding human Fab (F598) in complex with nona-N-acetyl-D-glucosamine (9NAc)

Summary for 6BE4

• Entry DOI: 10.2210/pdb6be4/pdb
• Related: 6BE2 6BE3
• Descriptor: Fab (F598) Heavy Chain, Fab(F598) Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: immunoglobulin, human antibody, antigen binding fragment, poly-n-acetylglucosamine, oligosaccharide, complex, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48331.50

Authors

Soliman, C.,Ramsland, P.A. (deposition date: 2017-10-24, release date: 2018-02-21, Last modification date: 2023-10-04)

• Primary citation: Soliman, C.,Walduck, A.K.,Yuriev, E.,Richards, J.S.,Cywes-Bentley, C.,Pier, G.B.,Ramsland, P.A.; Structural basis for antibody targeting of the broadly expressed microbial polysaccharide poly-N-acetylglucosamine.; J. Biol. Chem., 293:5079-5089, 2018; PubMed: 29449370; DOI: 10.1074/jbc.RA117.001170

Experimental method

X-RAY DIFFRACTION (1.9 Å)