6BC3

Cryo X-ray structure of sisomicin bound AAC-VIa

Summary for 6BC3

Entry DOI	10.2210/pdb6bc3/pdb
Descriptor	AAC 3-VI protein, COENZYME A, (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, ... (4 entities in total)
Functional Keywords	acetyltransferase, transferase-antibiotic complex, transferase/antibiotic
Biological source	Enterobacter cloacae
Total number of polymer chains	1
Total formula weight	33559.52
Authors	Cuneo, M.J.,Kumar, P.,Serpersu, E.H. (deposition date: 2017-10-20, release date: 2018-02-28, Last modification date: 2023-10-04)
Primary citation	Kumar, P.,Serpersu, E.H.,Cuneo, M.J. A low-barrier hydrogen bond mediates antibiotic resistance in a noncanonical catalytic triad. Sci Adv, 4:eaas8667-eaas8667, 2018 Cited by PubMed: 29632894 DOI: 10.1126/sciadv.aas8667 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.047 Å)

Structure validation