6BB1

Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one

Summary for 6BB1

• Entry DOI: 10.2210/pdb6bb1/pdb
• Related: 6BAD 6BAG 6BAX 6BB0 6BBZ
• Descriptor: L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: inhibitor, oxidoreductase, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 302143.85

Authors

Ultsch, M.,Eigenbrot, C. (deposition date: 2017-10-16, release date: 2018-10-24, Last modification date: 2023-11-15)

• Primary citation: Wei, B.,Labadie, S.S.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Goa, Z.,Ge, H.,Hitz, A.,Ho, Q.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.,Purkey, H.E.; Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.3 Å)