6B8Y

TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

6B8Y の概要

• エントリーDOI: 10.2210/pdb6b8y/pdb
• 分子名称: TGF-beta receptor type-1, N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
• 機能のキーワード: alk5, kinase domain, transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Single-pass type I membrane protein : P36897
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35539.77

構造登録者

Sheriff, S. (登録日: 2017-10-09, 公開日: 2018-02-07, 最終更新日: 2023-10-04)

• 主引用文献: Harikrishnan, L.S.,Warrier, J.,Tebben, A.J.,Tonukunuru, G.,Madduri, S.R.,Baligar, V.,Mannoori, R.,Seshadri, B.,Rahaman, H.,Arunachalam, P.N.,Dikundwar, A.G.,Fink, B.E.,Fargnoli, J.,Fereshteh, M.,Fan, Y.,Lippy, J.,Ho, C.P.,Wautlet, B.,Sheriff, S.,Ruzanov, M.,Borzilleri, R.M.; Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF beta RI).; Bioorg. Med. Chem., 26:1026-1034, 2018; PubMed: 29422332; DOI: 10.1016/j.bmc.2018.01.014

実験手法

X-RAY DIFFRACTION (1.65 Å)