6B8U

Crystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor

6B8U の概要

• エントリーDOI: 10.2210/pdb6b8u/pdb
• 分子名称: Serine/threonine-protein kinase B-raf, ~{N}-[3-(2-acetamidoimidazo[1,2-a]pyridin-6-yl)-4-methyl-phenyl]-3-(trifluoromethyl)benzamide (3 entities in total)
• 機能のキーワード: proto-oncogene b-raf, p94, v-raf murine sarcoma viral oncogene homolog b1, oncoprotein, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P15056
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64732.62

構造登録者

Appleton, B.A.,Murray, J.,Shafer, C.M. (登録日: 2017-10-09, 公開日: 2017-11-22, 最終更新日: 2023-10-04)

主引用文献

Smith, A.,Ni, Z.J.,Poon, D.,Huang, Z.,Chen, Z.,Zhang, Q.,Tandeske, L.,Merritt, H.,Shoemaker, K.,Chan, J.,Kaufman, S.,Huh, K.,Murray, J.,Appleton, B.A.,Cowan-Jacob, S.W.,Scheufler, C.,Kanazawa, T.,Jansen, J.M.,Stuart, D.,Shafer, C.M.
Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.
Bioorg. Med. Chem. Lett., 27:5221-5224, 2017

PubMed Abstract: A series of imidazo[1,2-a]pyridin-6-yl-benzamide analogs was designed as inhibitors of B-RAF. Medicinal chemistry techniques were employed to explore the SAR for this series and improve selectivity versus P38 and VEGFR2.

PubMed: 29107542
DOI: 10.1016/j.bmcl.2017.10.047

実験手法

X-RAY DIFFRACTION (2.68 Å)